Daddy Longlegs: Allows Isaac to easily clear most rooms or bosses while in statue form.It does better with slow or stationary bosses than regular enemies, diving in to attack periodically instead of harmlessly orbiting. Angry Fly: Aggressively attacks enemies even if they're far away, but can end up harmlessly orbiting slow or stationary enemies indefinitely, or trying to attack invulnerable enemies.At 30 damage or more, it surpasses Sacrificial Dagger.At 15 damage minimum, it surpasses most orbitals.
The locusts it produces often fly to Isaac which takes care of chasing enemies, but its damaging creep and chasing attacks can reach even the farthest enemies. The varied forms and attacks of this familiar make it capable of clearing pretty much any room given time. 7 Seals: One of the more versatile familiars that works with Gnawed Leaf.With items like Cube of Meat, Isaac can easily, but slowly, kill most enemies and bosses without taking any damage.While invulnerable, Little Horn’s pitfall still affects Isaac and will teleport him throughout the room however, the damage is not dealt.Bombs can be placed while stationary and safely be stood on until they blow up if no other inputs are done after placing the bomb.Using bombs and active items will remove the invincibility state.After standing still and not pressing the move or attack buttons for one second, Isaac will turn into an invincible statue.Upon pickup, Isaac gets a small brown ringtail.